Factor V Leiden Thrombophilia is a Point mutation and takes place as a missense substitution changes a proteins amino acid from Arginine to Glutamine. Factor v is a missense meaning it has different amino acids. Depending on the chosen start the chromosomal location of the nucleotide variant is either at position 1691 or 1746.It also affects the amino acid position for the variant, which is either 506 or 534. This disease is a Autosomal and is known as a Dominant gene.